Hydrochlorothiazide is the thiazide 'water pill' — a mild diuretic that makes the kidney pass a little more salt and water, and over weeks relaxes the blood vessels, which is what lowers blood pressure. It has been treating hypertension for sixty years, costs almost nothing, and is still one of the medicines international guidelines put first. In Nigeria it is taken by hundreds of thousands of people, most of them without knowing it: it is the second ingredient in the losartan-H, telmisartan-H, valsartan-H and amlodipine-valsartan-H combination tablets that fill pharmacy shelves.
In the NAFDAC register
125 registered products
from 59 registration holders
+5 more countries
What it costs online
Price varies — check with a pharmacy. This drug has not yet appeared in our fortnightly sampling of Nigerian online pharmacies.
Brands of Hydrochlorothiazide in Nigeria
Comes as
In combinations: Telmisartan + Hydrochlorothiazide · Amlodipine + Valsartan + Hydrochlorothiazide · Valsartan + Hydrochlorothiazide · Candesartan Cilexetil + Hydrochlorothiazide · Amiloride Hydrochloride + Hydrochlorothiazide · Losartan Potassium + Hydrochlorothiazide
Those 125 products from 59 registration holders, counted in our October 2026 copy of the register, include combination products and older listings; below are the most common brands.
| Brand Name | Manufacturer | Strength | Form | NAFDAC Reg. No. |
|---|---|---|---|---|
| Emzor Hydrochlorothiazide | Emzor Pharmaceutical Industries Limited | 25 mg | Tablet | A11-0946 |
| Donyhydro-25 | Dony-Triumph and Company Nigeria Limited | 25 mg | Tablet | A4-8215 |
| Esinil-25 | Transglobe Pharmaceutical Company Limited | 25 mg | Tablet | B4-5347 |
| Hydrex | Juhel Nigeria Limited | 25 mg | Tablet | A4-1209 |
Hydrochlorothiazide Price in Nigeria
Our sampled online pharmacies held no plain hydrochlorothiazide listing this cycle, so we quote no price. On its own it is one of the cheapest blood-pressure tablets a chemist sells, in strips of ten; most Nigerians take it inside a combination tablet with losartan, telmisartan, valsartan or amiloride, whose prices belong to those products. Ask a licensed pharmacy and check the NAFDAC number on the strip.
We show a price here once it appears in our monthly sampling of Nigerian online pharmacies (MedPlus, HealthPlus), or when we have a reliable market figure. For now, confirm the current price directly with a licensed pharmacy.
How to Verify Your Hydrochlorothiazide is Genuine
- 1Check the strip for its NAFDAC number and look it up. In our October 2026 copy of the register the current plain 25 mg tablets are Emzor Hydrochlorothiazide (A11-0946) and Esinil-25 (B4-5347); Donyhydro-25 (A4-8215) and IDA Foundation's Hydrochlorothiazide Tablets BP 25 mg (C4-1864) are recorded Inactive
- 2Hydrex Tablet 25 mg (A4-1209, Juhel) is recorded Expired since October 2023. A strip still on sale under that name should be checked by its printed number and expiry date, and a renewal confirmed on the official Greenbook
- 3A combination tablet (losartan-H, telmisartan-H, amlodipine-valsartan-H, amiloride-hydrochlorothiazide) carries its own registration under the combination's name — check that number, not a plain hydrochlorothiazide one
- 4Enter the number in our free NAFDAC checker and confirm the product name, strength and manufacturer match the pack
Where to Buy
Buying Hydrochlorothiazide wholesale, by the carton
Cartons of hydrochlorothiazide are bought at Nigeria's open drug markets: Idumota Market in Lagos, Ariaria Market in Aba, Ogbogwu Market in Onitsha and Sabon Gari Market in Kano. Each guide says where the market is and how to buy there safely; where we list sellers, they are named.
- Idumota Market, Lagos · wholesale sellers in Idumota Market
- Ariaria Market, Aba
- Ogbogwu Market, Onitsha
- Sabon Gari Market, Kano
No shop we list has Hydrochlorothiazide on its confirmed product list yet — the market guides still tell you where the trade happens and how to buy there safely.
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Wherever you buy, buy only from licensed pharmacies and verified distributors — not roadside vendors — and verify the pack's NAFDAC registration before you pay. Buying Hydrochlorothiazide in bulk or for resale? See how to buy medicines in bulk in Nigeria safely.
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What is Hydrochlorothiazide?
On its own the register is thin. In our October 2026 copy the current plain 25 mg tablets are Emzor Hydrochlorothiazide (A11-0946, made in Nigeria) and Esinil-25 (B4-5347); Donyhydro-25 (A4-8215) and an IDA Foundation generic (C4-1864) lapsed in 2026, and Hydrex (A4-1209, Juhel), the name many older patients still ask for, expired in October 2023. The combinations are another matter — dozens are current, led by telmisartan and amlodipine-valsartan pairings and the amiloride tablets that spare potassium. If your prescription says 'losartan-H' or 'Co-Diovan', this is the H.
It is a gentle drug with a few sharp edges. It lowers potassium and sodium, raises uric acid (gout) and blood sugar a little, and makes skin burn faster in the sun; years of use carry a small added risk of skin cancer, which matters more for fair skin than for most Nigerians but is still a reason to cover up. A blood test a few weeks after starting, and once a year after, catches the salt problems before they are felt.
What is Hydrochlorothiazide used for?
In Nigeria, Hydrochlorothiazide is commonly used for:
- High blood pressure, alone or in a combination tablet
- Mild oedema from heart failure, liver cirrhosis or kidney disease
- Preventing recurrent calcium kidney stones
- Nephrogenic diabetes insipidus (specialist use)
Dosage
IMPORTANT
Always follow your doctor's or pharmacist's instructions. The information below is for general reference only.
Adults
Hypertension: 12.5 to 25 mg once a day, in the morning. Doses above 25 mg add little blood-pressure benefit and more potassium loss, so the modern practice is to add a second drug rather than raise the thiazide. Oedema: 25 to 50 mg once a day, or on alternate days once fluid is controlled. In combination tablets the hydrochlorothiazide dose is fixed at 12.5 or 25 mg. Take it with or without food, early in the day so the extra urine does not disturb sleep.
Children
Used for hypertension and oedema in children at 1 to 2 mg per kg a day, prescribed and monitored by a paediatrician. Not for infants under six months outside specialist care.
Elderly
Start at 12.5 mg. Older people are more prone to low sodium and to dizziness on standing, and both come on quietly.
Blood pressure takes two to four weeks to settle; do not stop because the first week shows nothing. Eat potassium-rich food (bananas, beans, ugu, oranges) rather than taking supplements unless prescribed. In hot weather or during vomiting and diarrhoea the salt losses add up — drink, and seek advice if you feel weak, cramp or faint. Protect skin from the sun.
Side Effects
General information for a reader holding a pack, not a substitute for a doctor or pharmacist. If something on the serious list is happening, seek care now.
Common side effects
- •Passing more urine in the first days
- •Low potassium: tiredness, muscle cramps, palpitations
- •Dizziness on standing, especially at first and in hot weather
- •Raised uric acid, which can bring on gout in people prone to it
- •Slightly raised blood sugar and cholesterol
- •Skin that burns more easily in the sun; occasional rash
- •Erectile difficulty in some men
Serious side effects — seek medical help immediately
- Low sodium: confusion, severe weakness, seizures, especially in the elderly
- Severe low potassium with an irregular heartbeat
- Acute gout attack
- Acute angle-closure glaucoma — sudden eye pain and blurred vision in the first days or weeks (rare)
- Severe allergic reactions, including in people allergic to sulfonamide antibiotics
- A small increase in non-melanoma skin cancer with many years of use
When to see a doctor
Go to a clinic the same day for confusion, fainting, a racing or irregular heartbeat, or sudden eye pain with blurred vision. See a doctor within days for a swollen, hot, painful joint (gout), persistent cramps and weakness, or a rash. Have potassium and sodium checked a few weeks after starting and yearly after that.
Warnings & Precautions
General information for a reader holding a pack, not a substitute for a doctor or pharmacist. If something on the serious list is happening, seek care now.
Do not take Hydrochlorothiazide if you have:
- No urine output (anuria) or severe kidney failure
- Allergy to hydrochlorothiazide or to sulfonamide medicines
- Low potassium or low sodium that has not been corrected
- Addison's disease
- Gout or a history of it — use only with care and advice
Drug interactions
- •Lithium — thiazides raise lithium levels to toxic range; avoid
- •NSAIDs (ibuprofen, diclofenac) — blunt the blood-pressure effect and strain the kidneys
- •Digoxin — low potassium from the thiazide makes digoxin toxic
- •Corticosteroids and some laxatives — add to potassium loss
- •Other blood-pressure medicines — the intended additive effect; watch for dizziness
- •Diabetes medicines — blood sugar may need a small adjustment
- •Calcium and vitamin D supplements — thiazides retain calcium
Pregnancy & Breastfeeding
Not used for blood pressure in pregnancy: thiazides can reduce blood flow to the placenta and are not among the medicines chosen for pregnancy hypertension (methyldopa, nifedipine and labetalol are). A woman already taking it who becomes pregnant should see her doctor to switch. Small amounts pass into breast milk; low doses are generally considered compatible, though high doses can reduce milk supply.
Related Resources for Hydrochlorothiazide
Guides, articles, and tools related to Hydrochlorothiazide and other hypertension medicines in Nigeria.
Frequently Asked Questions
Sources
- •NAFDAC Greenbook — the official database of all products registered with Nigeria's National Agency for Food and Drug Administration and Control. Brand-level NAFDAC numbers for Hydrochlorothiazide on this page were cross-referenced against the Greenbook.
- •WHO Model List of Essential Medicines — Hydrochlorothiazide is included in the WHO's list of essential medicines, meaning it is considered essential for basic healthcare needs.
- •British National Formulary (BNF) dosing and interaction guidance for Hydrochlorothiazide.
- •Nigerian Standard Treatment Guidelines (Federal Ministry of Health).
Daily puzzle: Meddle — pair five brands with their medicines. New game at midnight.