Omeprazole is one of the most commonly used medications in Nigeria, widely known as "the ulcer drug." Walk into virtually any pharmacy or patent medicine store across the country — from Ikeja to Kano, Enugu to Port Harcourt — and you will find omeprazole on the shelf. It belongs to a class of drugs called proton pump inhibitors (PPIs), which work by reducing the amount of acid produced in the stomach. This makes it highly effective for treating peptic ulcers, acid reflux, and other conditions caused by excess stomach acid. In Nigeria, where the prevalence of peptic ulcer disease is high, omeprazole has become a household name.
In the NAFDAC register
194 registered products
from 148 registration holders
+1 more country
What it costs online
about ₦2,200
≈₦182 per tablet (tablet/capsule)
0% since July 2026 · like-for-like
Sampled from 5 listings across HealthPlus and MedPlus and Supermart.ng · October 2026
Full price breakdown →Brands of Omeprazole in Nigeria
Comes as
- Capsule20 mg· ₦1,200–₦2,200
- Powder for injection40 mg· 15 makers
Those 194 products from 148 registration holders, counted in our October 2026 copy of the register, include combination products and older listings; below are the most common brands.
| Brand Name | Manufacturer | Strength | Form | NAFDAC Reg. No. |
|---|---|---|---|---|
| Losec | AstraZeneca | 20mg, 40mg | Capsule | |
| Risek | Julphar | 20mg, 40mg | Capsule | |
 | Dr. Reddy's | 20mg | Capsule | |
 | Getz Pharma | 20mg, 40mg | Capsule | A4-9554 |
 | Getz Pharma | 20mg, 40mg | Suspension | A4-9826 |
| Meprasil | Fidson Healthcare PLC | 40mg | Powder for injection | 04-5478 |
| Omefast-20 | Greenlife Pharmaceutical Limited | 20mg | Capsule | 04-5325 |
 | Shalina Healthcare Nigeria Limited | 40mg, 20mg | Powder for injection | B4-9347 |
Omeprazole Price in Nigeria
As of October 2026, Omeprazole tablets sell for about ₦182 per tablet online in Nigeria (packs ₦1,200–₦4,375; Omeshal, Getzome, Meprasil) at three online pharmacies. The online price is roughly unchanged since July 2026. Open-market prices (e.g. Idumota, Ogbogwu) are often lower.
Online retail (sampled)
₦1,910 for 20 tablets
₦2,200 for 10 tablets
Same 20mg Omeprazole — 2.3× the price, tablet for tablet.
median ₦2,200 · 5 listings
Better valueMeprasil Omeprazole 20mg x20(HealthPlus)
₦1,910₦96 per tabletCosts moreOMESHAL D *10CAPS (OMEPRAZOLE)(MedPlus)
₦2,200₦220 per tablet5 listings across HealthPlus + MedPlus + Supermart.ng — brands and pack sizes vary · October 2026.
Unchanged since July 2026.
Omeprazole price by brand
Each brand's own listings, as its page states them — the range above spans every brand and pack size.
- Omeshal price₦1,200–₦2,200· 2 listings
- Getzome price₦2,550· 1 listing
- Meprasil price₦1,910· 1 listing
How to Verify Your Omeprazole is Genuine
- 1Check the NAFDAC registration number on the packaging — all genuine omeprazole products sold in Nigeria must carry a valid NAFDAC number
- 2Verify the NAFDAC number using the NAFDAC Green Book website or the NAFDAC mobile verification app available on Android and iOS
- 3Purchase from licensed pharmacies or registered patent medicine stores only — avoid buying from open markets, bus stops, or unregistered vendors
- 4Inspect the packaging for the manufacturer's details, batch number, manufacturing date, and expiry date — all should be clearly printed
- 5Genuine omeprazole capsules should have a consistent appearance — if the capsules look discoloured, damaged, or the contents appear different from usual, do not take them
- 6For major brands, check for additional security features such as holographic seals or QR codes on the packaging
Where to Buy
Listed sellers stocking Omeprazole brands
As stated by each shop — not live inventory. Confirm availability with the shop, and verify the NAFDAC registration on any pack before you buy.
By market: Where to buy omeprazole in Idumota Market, Lagos (1 seller)
Buying Omeprazole wholesale, by the carton
Cartons of omeprazole are bought at Nigeria's open drug markets: Idumota Market in Lagos, Ariaria Market in Aba, Ogbogwu Market in Onitsha and Sabon Gari Market in Kano. Each guide says where the market is and how to buy there safely; where we list sellers, they are named.
- Idumota Market, Lagos · wholesale sellers in Idumota Market — 1 listed seller here carries Omeprazole brands
- Ariaria Market, Aba
- Ogbogwu Market, Onitsha
- Sabon Gari Market, Kano
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What is Omeprazole?
Omeprazole works by irreversibly blocking the hydrogen-potassium ATPase enzyme system (the proton pump) in the stomach lining, which is the final step in acid production. By shutting down these acid pumps, omeprazole dramatically reduces stomach acid secretion, allowing ulcers to heal and preventing new ones from forming. It is a key component of the triple therapy regimen used to eradicate Helicobacter pylori (H. pylori), a bacterium responsible for the majority of peptic ulcers in Nigeria. The triple therapy typically combines omeprazole with two antibiotics — amoxicillin and either metronidazole or clarithromycin — and is widely prescribed across the country.
Omeprazole is available in Nigeria under several brand names including Losec (the original brand by AstraZeneca), Risek, and Omez, alongside generic omeprazole from a number of manufacturers. All legitimate brands must carry a NAFDAC registration number. While omeprazole is available over the counter in most Nigerian pharmacies, it is important to understand that self-medicating for persistent stomach pain without proper diagnosis can mask serious conditions including stomach cancer. If your symptoms persist beyond two weeks, you should see a doctor for proper evaluation.
What is Omeprazole used for?
In Nigeria, Omeprazole is commonly used for:
- Treatment of stomach (gastric) and duodenal ulcers — the most common reason Nigerians take omeprazole
- Gastroesophageal reflux disease (GERD), commonly known as acid reflux or heartburn
- H. pylori eradication as part of triple therapy (omeprazole + amoxicillin + metronidazole or clarithromycin)
- Prevention of stomach ulcers caused by regular use of NSAIDs such as ibuprofen, diclofenac, and aspirin
- Zollinger-Ellison syndrome and other conditions involving excessive stomach acid production
- Relief of symptoms of dyspepsia (indigestion) and epigastric pain
Dosage
IMPORTANT
Always follow your doctor's or pharmacist's instructions. The information below is for general reference only.
Adults
For peptic ulcer: 20mg once daily for 4 to 8 weeks. For GERD: 20mg once daily for 4 weeks, may be increased to 40mg if needed. For H. pylori triple therapy: 20mg twice daily for 7 to 14 days alongside antibiotics. For NSAID-associated ulcer prevention: 20mg once daily. Take the capsule 30 minutes before a meal, preferably in the morning before breakfast.
Children
Omeprazole is generally used in children over 1 year of age under medical supervision. Dosing is weight-based: children weighing 10-20kg may take 10mg once daily, while those over 20kg may take 20mg once daily. Always consult a paediatrician before giving omeprazole to a child.
Elderly
Standard adult doses are generally appropriate for elderly patients. However, elderly individuals with liver impairment may require lower doses. A maximum daily dose of 20mg is recommended for those with severe liver problems.
Omeprazole capsules should be swallowed whole with a glass of water — do not crush, chew, or open the capsules, as the granules inside are specially coated to resist stomach acid. Take it 30 minutes before meals for maximum effectiveness. If you are on triple therapy for H. pylori, complete the full course of antibiotics even if you feel better. Do not take omeprazole continuously for more than 8 weeks without medical review.
Side Effects
General information for a reader holding a pack, not a substitute for a doctor or pharmacist. If something on the serious list is happening, seek care now.
Common side effects
- •Headache — one of the most frequently reported side effects
- •Diarrhoea or constipation
- •Nausea, stomach pain, or flatulence (gas)
- •Dizziness
Serious side effects — seek medical help immediately
- Vitamin B12 deficiency with long-term use (more than 3 years), which can cause tiredness and numbness
- Increased risk of bone fractures (hip, wrist, spine) with long-term, high-dose use
- Clostridium difficile-associated diarrhoea — severe, persistent, watery diarrhoea that requires medical attention
- Low magnesium levels (hypomagnesaemia) with prolonged use, which can cause muscle cramps and irregular heartbeat
- Severe allergic reactions including skin rash, swelling, and difficulty breathing — rare but seek emergency care
When to see a doctor
See a doctor if you experience persistent diarrhoea, severe stomach pain, unexplained weight loss, difficulty swallowing, vomiting blood, or black tarry stools while taking omeprazole. These could indicate a more serious condition that needs investigation. Also consult a doctor if your symptoms do not improve after two weeks of treatment, or if you have been taking omeprazole for more than 8 weeks without medical supervision.
Warnings & Precautions
General information for a reader holding a pack, not a substitute for a doctor or pharmacist. If something on the serious list is happening, seek care now.
Do not take Omeprazole if you have:
- Do not take if you have a known allergy to omeprazole or any other proton pump inhibitor (such as esomeprazole, lansoprazole, or pantoprazole)
- Do not take with the HIV medication rilpivirine (Edurant) or nelfinavir, as omeprazole significantly reduces their effectiveness
- Exercise caution if you have severe liver disease — a reduced dose may be necessary
Drug interactions
- •Clopidogrel (Plavix) — omeprazole reduces the effectiveness of this blood-thinning medication; your doctor may switch you to a different PPI
- •Methotrexate — omeprazole can increase methotrexate levels in the blood, raising the risk of toxicity
- •Diazepam (Valium) — omeprazole may increase diazepam levels and prolong its effects
- •Warfarin — omeprazole may enhance the blood-thinning effect of warfarin; INR monitoring is advised
- •Ketoconazole and itraconazole — omeprazole reduces stomach acid needed for absorption of these antifungals
- •Iron supplements — reduced stomach acid may decrease iron absorption
Pregnancy & Breastfeeding
Omeprazole should be used during pregnancy only if clearly needed and prescribed by a doctor. While animal studies have not shown direct harm, there is limited data in pregnant women. It is classified as Category C in pregnancy. Omeprazole passes into breast milk in small amounts. If you are breastfeeding, consult your doctor before taking omeprazole. For occasional heartburn during pregnancy, simpler antacids may be a safer first option.
Used for these conditions
Related Resources for Omeprazole
Guides, articles, and tools related to Omeprazole and other digestive health medicines in Nigeria.
Frequently Asked Questions
Sources
- •NAFDAC Greenbook — the official database of all products registered with Nigeria's National Agency for Food and Drug Administration and Control. Brand-level NAFDAC numbers for Omeprazole on this page were cross-referenced against the Greenbook.
- •WHO Model List of Essential Medicines — Omeprazole is included in the WHO's list of essential medicines, meaning it is considered essential for basic healthcare needs.
- •British National Formulary (BNF) dosing and interaction guidance for Omeprazole.
- •Nigerian Standard Treatment Guidelines (Federal Ministry of Health).
Daily puzzle: Meddle — pair five brands with their medicines. New game at midnight.