Ampicillin plus cloxacillin is a fixed combination of two penicillin antibiotics, and in Nigeria it is one of the most recognised medicines on the market under the name Ampiclox. Ampicillin covers a broad range of bacteria including many gram-negatives; cloxacillin is specifically resistant to the penicillinase enzyme that Staphylococcus aureus uses to destroy ordinary penicillin. The idea of the combination is to cover both at once.
In the NAFDAC register
56 registered products
from 35 registration holders
What it costs online
Our sampling found 2 listings (August 2026) — every one of them Ampiclox, listed at ₦3,180–₦7,410. That is Ampiclox's price, not the molecule's — one brand's price cannot honestly stand for a molecule the register lists under many, so no market-wide figure is shown — see the Ampiclox page for what those listings cost.
Brands of Ampicillin + Cloxacillin in Nigeria
Comes as
Those 56 products from 35 registration holders include combination products and older listings; below are the most common brands.
| Brand Name | Manufacturer | Strength | Form | NAFDAC Reg. No. |
|---|---|---|---|---|
 | GlaxoSmithKline Consumer Nigeria | 250mg + 250mg | Capsule | 04-2401 |
 | SKG - Pharma Ltd | 250mg + 250mg | Capsule | A4-4154 |
| Euroclox Capsule | Chris-Ejik Pharmaceuticals & Healthcare Products Limited | 250mg + 250mg | Capsule | 04-3059 |
| Miraclox Capsules | Miraflash Nig Ltd | 250mg + 250mg | Capsule | A11-0038 |
| Avroclox Suspension | Avro Pharma Limited | 125mg/5ml + 125mg/5ml | Suspension | A4-5669 |
| Compi-Clox Powder for Oral Suspension | Drugfield Pharmaceuticals Limited | 125mg/5ml + 125mg/5ml | Suspension | 04-2350 |
Ampicillin + Cloxacillin Price in Nigeria
Ampicillin + Cloxacillin prices in Nigeria vary by brand, strength, and where you buy it. Confirm the current price with a licensed pharmacy, and always check the product is NAFDAC-registered before you pay.
We show a price here once it appears in our monthly sampling of Nigerian online pharmacies (MedPlus, HealthPlus), or when we have a reliable market figure. For now, confirm the current price directly with a licensed pharmacy.
How to Verify Your Ampicillin + Cloxacillin is Genuine
- 1Check the NAFDAC number on the pack — Ziclox carries A4-4154, Euroclox 04-3059, Miraclox A11-0038, Avroclox Suspension A4-5669 and Compi-Clox 04-2350 in our copy of the register.
- 2Confirm any brand with our NAFDAC checker. Twenty-one companies hold active registrations, so a genuine product should be findable.
- 3Avoid loose capsules sold by the piece. This is one of the most counterfeited antibiotic presentations in West Africa, and a capsule without a pack cannot be verified at all.
- 4Check the expiry date and that the blister foil is intact and crisply printed.
- 5Most registered products in this class are made in Nigeria — a locally made, register-verified brand is a sound choice here, not a compromise.
Where to Buy
Buying Ampicillin + Cloxacillin by the carton
Cartons are bought at Nigeria's four open drug markets. Each guide names the sellers there you can contact, and how to buy safely:
No shop we list has Ampicillin + Cloxacillin on its confirmed product list yet — the market guides still tell you where the trade happens and how to buy there safely.
Wherever you buy, buy only from licensed pharmacies and verified distributors — not roadside vendors — and verify the pack's NAFDAC registration before you pay. Buying Ampicillin + Cloxacillin in bulk or for resale? See how to buy medicines in bulk in Nigeria safely.
Need Ampicillin + Cloxacillin in bulk, or can't find it near you?
Tell us what you need and we'll connect you with a verified, NAFDAC-registered source.
What is Ampicillin + Cloxacillin?
Our copy of the NAFDAC register shows twenty-nine active registrations of this combination from twenty-one companies, and — unusually — the great majority are made in Nigeria: Ziclox from SKG, Euroclox from Chris-Ejik, Miraclox, Avroclox, Compi-Clox from Drugfield, Cloxypak and many more. This is genuinely a locally manufactured medicine, well supplied and cheap.
It also has to be said plainly that this combination is heavily over-used in Nigeria. It is bought over the counter for coughs and colds that are viral, taken for a day or two and stopped, and used to 'flush the system' after unprotected sex or before travel — none of which it does. Fixed-dose combinations of two antibiotics are not recommended by most modern guidelines, which prefer to choose one appropriate antibiotic for the organism suspected. Every unnecessary course pushes resistance further along.
What is Ampicillin + Cloxacillin used for?
In Nigeria, Ampicillin + Cloxacillin is commonly used for:
- Skin and soft-tissue infections including boils, abscesses and infected wounds, where staphylococci are likely
- Respiratory tract infections, on a doctor's judgement
- Ear, nose and throat infections such as otitis media and tonsillitis
- Infected surgical or obstetric wounds
- Mixed infections where both staphylococcal and broader cover is wanted
- Bone and joint infections, usually with the injectable form in hospital
Dosage
IMPORTANT
Always follow your doctor's or pharmacist's instructions. The information below is for general reference only.
Adults
The usual adult dose is one 500mg capsule (250mg ampicillin plus 250mg cloxacillin) four times daily — every six hours — taken on an empty stomach, at least an hour before food or two hours after. Both penicillins absorb considerably better without food, and this genuinely matters for whether the medicine works. A course is normally five to seven days, and must be completed even after symptoms improve. More severe infections may need the injectable form in hospital.
Children
Children are dosed by weight using the 125mg/5ml suspension, typically around 50mg per kg per day of the combination split into four doses. The powder is reconstituted with clean water to the mark on the bottle, shaken well before each dose, measured with a proper syringe or measuring spoon, and kept refrigerated once mixed — most reconstituted suspensions last only seven days. Confirm the dose with a pharmacist against the child's weight.
Elderly
Older adults tolerate penicillins well in general, but the four-times-daily schedule is hard to keep to, and doses are reduced in significant kidney impairment. Missed doses matter more with a short-acting antibiotic than with a once-daily one.
TAKE IT ON AN EMPTY STOMACH — this is the most common practical mistake with this medicine, and food substantially reduces how much is absorbed. Complete the full course; stopping when you feel better is how resistance is bred. And be clear about what this medicine does not do: it does not treat malaria, it does not treat viral coughs, colds or flu, and it does not prevent sexually transmitted infections. Taking it after unprotected sex is a widespread practice in Nigeria that provides no protection and drives resistance.
Side Effects
Common side effects
- •Diarrhoea and loose stools
- •Nausea and stomach upset
- •Oral or vaginal thrush after a course
- •Skin rash
- •Altered taste
Serious side effects — seek medical help immediately
- Anaphylaxis — sudden severe allergic reaction with facial swelling and breathing difficulty
- Clostridioides difficile-associated diarrhoea — severe, persistent or bloody
- Severe skin reactions including Stevens-Johnson syndrome — rare
- Cholestatic jaundice, more associated with the cloxacillin component
- Blood-count abnormalities and, at high doses in kidney impairment, seizures
When to see a doctor
Seek emergency care for swelling of the face, lips or throat, wheezing or difficulty breathing — a penicillin allergy can be immediate and life-threatening. See a doctor promptly for a widespread or blistering rash, for severe or bloody diarrhoea, or for yellowing of the eyes or skin. If the infection has not improved after 48 to 72 hours, return to the clinic rather than adding another antibiotic yourself.
Warnings & Precautions
Do not take Ampicillin + Cloxacillin if you have:
- Known allergy to penicillin or to any beta-lactam antibiotic
- Previous severe skin reaction or jaundice on a penicillin
- Infectious mononucleosis (glandular fever) — ampicillin causes a widespread rash in most people with it
- Use with caution and dose adjustment in significant kidney impairment
Drug interactions
- •Hormonal contraceptives — reduced effectiveness is possible if the antibiotic causes vomiting or diarrhoea; use additional protection during the course and for seven days after
- •Methotrexate — penicillins reduce its clearance and increase toxicity
- •Allopurinol — increases the likelihood of an ampicillin rash
- •Warfarin — penicillins can affect the INR; monitor if you take it
- •Live oral typhoid vaccine — the antibiotic blunts it; separate the two
- •Probenecid — raises and prolongs penicillin blood levels
Pregnancy & Breastfeeding
Penicillins are among the antibiotics best established as safe in pregnancy, and ampicillin has a long record of use across all trimesters when an antibiotic is genuinely needed. Small amounts pass into breast milk; breastfeeding is normally continued while watching the infant for loose stools or thrush. As with any antibiotic in pregnancy, it should be prescribed rather than self-selected.
Related Resources for Ampicillin + Cloxacillin
Guides, articles, and tools related to Ampicillin + Cloxacillin and other antibiotics medicines in Nigeria.
Frequently Asked Questions
Sources
- •NAFDAC Greenbook — the official database of all products registered with Nigeria's National Agency for Food and Drug Administration and Control. Brand-level NAFDAC numbers for Ampicillin + Cloxacillin on this page were cross-referenced against the Greenbook.
- •British National Formulary (BNF) dosing and interaction guidance for Ampicillin + Cloxacillin.
- •Nigerian Standard Treatment Guidelines (Federal Ministry of Health).
Daily puzzle: Meddle — pair five brands with their medicines. New game at midnight.